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P 158. Neural correlates of Hebbian and anti-hebbian spike-timing-dependent plasticity in human: A TMS–EEG combined study

Veniero, D ; Ponzo, V ; Caltagirone, C ; Koch, G

Clinical Neurophysiology, October 2013, Vol.124(10), pp.e139-e139 [Peer Reviewed Journal]

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  • Title:
    P 158. Neural correlates of Hebbian and anti-hebbian spike-timing-dependent plasticity in human: A TMS–EEG combined study
  • Author: Veniero, D ; Ponzo, V ; Caltagirone, C ; Koch, G
  • Description: In a recent work by our group we used transcranial magnetic stimulation (TMS) to repeatedly activate the connection between the posterior parietal cortex (PPC) and the primary motor cortex (M1) of the left dominant hemisphere with a paired associative stimulation (PAS) protocol. By varying inter-pulse interval and the activation of different M1 neuronal populations we were able to induce LTP or LTD-like effects as indexed by Motor Evoked Potentials (MEPs) amplitude modulation that followed either Hebbian or anti-Hebbian temporal rules. Our aim was to further investigate the effects induced by this cortico-cortical PAS protocol over EEG activity, by means of a TMS–EEG coregistration approach. 13 volunteers underwent our novel PAS protocol. Paired stimuli were applied with PPC-TMS preceding (+5ms) or following (−5ms) M1 stimulation. In a third condition, the induced current direction over M1 was changed from postero–anterior (PA) to antero–posterior...
  • Is Part Of: Clinical Neurophysiology, October 2013, Vol.124(10), pp.e139-e139
  • Identifier: ISSN: 1388-2457 ; E-ISSN: 1872-8952 ; DOI: 10.1016/j.clinph.2013.04.235
  • Subjects: Medicine
  • Language: English
  • Source: ScienceDirect Journals (Elsevier)

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