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Transformation of aqueous sulfonamides under horseradish peroxidase and characterization of sulfur dioxide extrusion products from sulfadiazine

Yang, Lihua ; Shi, Yang ; Li, Jinjin ; Fang, Ling ; Luan, Tiangang

Chemosphere, June 2018, Vol.200, pp.164-172 [Peer Reviewed Journal]

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  • Title:
    Transformation of aqueous sulfonamides under horseradish peroxidase and characterization of sulfur dioxide extrusion products from sulfadiazine
  • Author: Yang, Lihua ; Shi, Yang ; Li, Jinjin ; Fang, Ling ; Luan, Tiangang
  • Description: The potential of horseradish peroxidase (HRP) to catalyze the removal of sulfonamides from water and the effects of different H O and HRP concentrations were investigated. Six sulfonamides, each with a five- or six-membered heterocyclic group, including sulfamethoxazole (SMX), sulfathiazole (STZ), sulfapyridine (SPD), sulfadiazine (SDZ), sulfamerazine (SMR) and sulfamethoxypyridazine (SMP) were selected as target compounds. All sulfonamides exhibit a pseudo-first-order dependence of the concentration versus the reaction time. The decay rate ( , h ) of the six sulfonamides spiked individually exhibit a trend following the order of STZ > SMP, SPD > SMR > SDZ » SMX. When spiked together, the coexistent sulfonamides might act as mediators for the enhancement of SMX removal and as competitors for the decreased removal of most sulfonamides. Moreover, six transformation products of SDZ are identified by the Thermo Scientific LTQ Orbitrap Elite technique. SDZ transformation involves two steps: one is the Smiles re-arrangement of the structure, and the other is oxidation and sulfur dioxide extrusion. This study is the first to report the removal dynamics of sulfonamides in HRP-catalyzed reactions and the identified products of SDZ.
  • Is Part Of: Chemosphere, June 2018, Vol.200, pp.164-172
  • Identifier: ISSN: 0045-6535 ; E-ISSN: 1879-1298 ; DOI: 10.1016/j.chemosphere.2018.01.118
  • Subjects: Sulfonamides ; Horseradish Peroxidase ; Sulfur Dioxide Extrusion ; Smiles Re-Arrangement ; Chemistry ; Ecology
  • Language: English

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