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N-Aryl 2,6-Dimethoxybiphenylalanine Analogues as VLA-4 Antagonists

Doherty, George A ; Kamenecka, Theodore ; Mccauley, Ermenegilda ; Van Riper, Gail ; Mumford, Richard A ; Tong, Sharon ; Hagmann, William K

Bioorganic & Medicinal Chemistry Letters, 2002, Vol.12(5), pp.729-731 [Peer Reviewed Journal]

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Title:
N-Aryl 2,6-Dimethoxybiphenylalanine Analogues as VLA-4 Antagonists
Author: Doherty, George A ; Kamenecka, Theodore ; Mccauley, Ermenegilda ; Van Riper, Gail ; Mumford, Richard A ; Tong, Sharon ; Hagmann, William K
Description: A series of N-arylated phenylalanine derivatives has been synthesized and has been shown to be potent inhibitors of the integrin VLA-4. N-phenyl and N-heteroaryl derivatives with hydrogen bond acceptors in the meta position demonstrated low nanomolar activity against VLA-4.
Is Part Of: Bioorganic & Medicinal Chemistry Letters, 2002, Vol.12(5), pp.729-731
Identifier: ISSN: 0960-894X ; E-ISSN: 1464-3405 ; DOI: 10.1016/S0960-894X(02)00009-4
Subjects: Medicine ; Chemistry ; Anatomy & Physiology
Language: English

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