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Quinazolinones 1: design and synthesis of potent quinazolinone- containing AT 1-selective angiotensin-II receptor antagonists

Allen, Eric E ; de Laszlo, Stephen E ; Huang, Song X ; Quagliato, Carol S ; Greenlee, William J ; Chang, Raymond S.L ; Chen, Tsing-Bau ; Faust, Kristie A ; Lotti, Victor J

Bioorganic & Medicinal Chemistry Letters, 1993, Vol.3(6), pp.1293-1298 [Peer Reviewed Journal]

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  • Title:
    Quinazolinones 1: design and synthesis of potent quinazolinone- containing AT 1-selective angiotensin-II receptor antagonists
  • Author: Allen, Eric E ; de Laszlo, Stephen E ; Huang, Song X ; Quagliato, Carol S ; Greenlee, William J ; Chang, Raymond S.L ; Chen, Tsing-Bau ; Faust, Kristie A ; Lotti, Victor J
  • Description: We present the design, syntheses, and in vitro biological data of a series of substituted quinazolinone containing, AT 1 selective, Angiotensin II (AII) receptor antagonists. Substituents at the 6-position of the quinazolin-4(3H)-ones 3 have pronounced effects on the vitro potency related to both their electronic and lipophilic character. We describe three synthetic routes to a series of quinazolin-4(3H)-ones 3 . These compounds are selective antagonists of Angiotensin II at the AT 1 receptor. Substituents at the 6-position of the quinazolinone have pronounced effects on the in vitro potency related to both their electronic and lipophilic character.
  • Is Part Of: Bioorganic & Medicinal Chemistry Letters, 1993, Vol.3(6), pp.1293-1298
  • Identifier: ISSN: 0960-894X ; E-ISSN: 1464-3405 ; DOI: 10.1016/S0960-894X(00)80334-0
  • Subjects: Medicine ; Chemistry ; Anatomy & Physiology
  • Language: English

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