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Synthesis of the C12–C26 fragment of the acyltetronic acid lonophore antibiotic tetronasin (ici 139603)

de Laszlo, Stephen E ; Ford, Mark J ; Ley, Steven V ; Maw, Graham N

Tetrahedron Letters, 1990, Vol.31(38), pp.5525-5528 [Peer Reviewed Journal]

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  • Title:
    Synthesis of the C12–C26 fragment of the acyltetronic acid lonophore antibiotic tetronasin (ici 139603)
  • Author: de Laszlo, Stephen E ; Ford, Mark J ; Ley, Steven V ; Maw, Graham N
  • Description: Preparation of a central tetrahydropyran portion (2) of the antibiotic tetronasin (1) was achieved using an all-in-one epoxidation / cyclization modification of the Sharpless reaction. Further manipulation and coupling reactions afforded the C12–C26 fragment of tetronasin which was identical to that obtained by natural product degradation studies. Preparation of a tetrahydropyran portion (2) of the antibiotic tetronasin (1) has been achieved. Further manipulation afforded the C12–C26 (3) fragment of tetronasin, identical to that obtained by natural product degradation.
  • Is Part Of: Tetrahedron Letters, 1990, Vol.31(38), pp.5525-5528
  • Identifier: ISSN: 0040-4039 ; E-ISSN: 1873-3581 ; DOI: 10.1016/S0040-4039(00)97889-4
  • Subjects: Chemistry
  • Language: English

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