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Faster Cognitive and Functional Decline in Dysexecutive versus Amnestic Alzheimer's Subgroups: A Longitudinal Analysis of the National Alzheimer's Coordinating Center (NACC) Database

Mez, Jesse ; Cosentino, Stephanie ; Brickman, Adam M. ; Huey, Edward D. ; Manly, Jennifer J. ; Mayeux, Richard Paul

2013

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  • Title:
    Faster Cognitive and Functional Decline in Dysexecutive versus Amnestic Alzheimer's Subgroups: A Longitudinal Analysis of the National Alzheimer's Coordinating Center (NACC) Database
  • Author: Mez, Jesse ; Cosentino, Stephanie ; Brickman, Adam M. ; Huey, Edward D. ; Manly, Jennifer J. ; Mayeux, Richard Paul
  • Description: Objective: To compare the rate of cognitive and functional decline in dysexecutive, typical and amnestic subgroups of Alzheimer’s disease. Methods: 943 participants from the National Alzheimer’s Coordinating Center (NACC) database who had a diagnosis of probable AD were followed for a mean of 2.3 years. A dysexecutive subgroup (n = 165) was defined as having executive performance > 1.5 SD worse than memory performance, an amnestic subgroup (n = 157) was defined as having memory performance > 1.5 SD worse than executive performance and a typical subgroup (n = 621) was defined as having a difference in executive and memory performance of < 1.5 SD. Generalized estimating equations (GEE) were used to model decline on the Folstein Mini Mental Status Exam (MMSE), rise on the Clinical Dementia Rating (CDR) sum of boxes and rise on the total Functional Assessment Questionnaire (FAQ). Results: Compared with the amnestic subgroup, the dysexecutive subgroup declined 2.2X faster on the Folstein MMSE (p<.001), rose 42% faster on the CDR sum of boxes (p = .03) and rose 33% faster on the total FAQ (p = .01). Rate of change for the typical subgroup fell between that of the amnestic and dysexecutive subgroups for the MMSE,...
  • Publication Date: 2013
  • Publisher: Columbia University
  • Identifier: DOI: 10.7916/D8X357GH ; Related ISSN: 1932-6203 ; Related ISBN: ; Related DOI: 10.1371/journal.pone.0065246
  • Subjects: Neurosciences
  • Source: DataCite

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