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Esophageal Atresia: Gastroesophageal functional follow-up in 5–15 year old children

Pedersen, Rikke Neess ; Markøw, Simone ; Kruse-Andersen, Søren ; Qvist, Niels ; Hansen, Tine Plato ; Gerke, Oke ; Nielsen, Rasmus Gaardskær ; Rasmussen, Lars ; Husby, Steffen

Journal of Pediatric Surgery, December 2013, Vol.48(12), pp.2487-2495 [Peer Reviewed Journal]

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  • Title:
    Esophageal Atresia: Gastroesophageal functional follow-up in 5–15 year old children
  • Author: Pedersen, Rikke Neess ; Markøw, Simone ; Kruse-Andersen, Søren ; Qvist, Niels ; Hansen, Tine Plato ; Gerke, Oke ; Nielsen, Rasmus Gaardskær ; Rasmussen, Lars ; Husby, Steffen
  • Description: PurposeEsophageal atresia (EA) is one of the most frequent congenital alimentary tract anomalies with a considerable morbidity throughout childhood. This study evaluates the gastroesophageal problems in 5–15year old children with EA and aims to identify factors predisposing to esophagitis in EA. Material and methodsFifty-nine patients primarily operated at Odense University Hospital, Denmark, during 1993–2005 were included in this follow-up study. The patients underwent the following examinations: Interview, upper endoscopy, endoscopic ultrasonography, high-resolution esophageal manometry (HREM), and pH- and multichannel intraluminal impedance (MII) measurements. Twenty-five patients with suspected gastro-esophageal reflux disease (GERD) underwent the same investigations and served as controls. ResultsMedian age was 10.2years (7.1–13.3). Thirty-three (55.9%) presented with GERD symptoms, 41 (69.5%) with dysphagia, and 33 (55.9%) with respiratory symptoms. Twenty-nine (49.2%) had endoscopic esophagitis, and 26 (44.1%) histological esophagitis. Median reflux index (RI) was 8.3 (4.8–14.9). In 32 (55.2%) RI was above 7. Ten percent had eosinophilic inflammation. HREM showed dysmotility in the esophagus in all EA patients, 83.3% had no propagating swallows. No predictive factors predisposing the development of endoscopic esophagitis were identified. ConclusionsGastroesophageal problems in children born with EA are common. Routine follow-up with endoscopy and pH-metry in EA patients is warranted.
  • Is Part Of: Journal of Pediatric Surgery, December 2013, Vol.48(12), pp.2487-2495
  • Identifier: ISSN: 0022-3468 ; DOI: 10.1016/j.jpedsurg.2013.07.019
  • Subjects: Esophageal Atresia ; Children ; Esophageal Motility Disorders ; Gastroesophageal Reflux Disease ; Upper Endoscopy ; High Resolution Esophageal Manometry
  • Language: English

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