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Pentachlorophenol affected both reproductive and interrenal systems: In silico and in vivo evidence

Yang, Lihua ; Zha, Jinmiao ; Wang, Zijian

Chemosphere, January 2017, Vol.166, pp.174-183 [Peer Reviewed Journal]

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  • Title:
    Pentachlorophenol affected both reproductive and interrenal systems: In silico and in vivo evidence
  • Author: Yang, Lihua ; Zha, Jinmiao ; Wang, Zijian
  • Description: The present study investigated the effects on reproductive and interrenal system by pentachlorophenol (PCP) using and assays. Molecular docking results indicated interacting potency of PCP with steroid receptors (ERα, ERβ, AR, GR) but not Cytochrome P450 enzymes (CYPs). In the assay, sexually matured rare minnow ( ) was exposed to environmental relevant concentrations of PCP (0, 0.5, 5, 50 μg L ). In male fish, 14-d exposure caused up-regulation of mRNA levels of hepatic , , and gonadal , , , providing evidence for agonistic activities for steroid receptors by PCP. The up-regulated mRNA of , , in the brain also indicated feed-forward responses of the hypothalamic-pituitary-gonadal/interrenal (HPG/I) axis. However, at 28th d the feed-forward response of the HPG axis seemed eased back and the HPI axis showed negative feedback responses. Corresponding changes including increases of plasma steroid hormones, inhibition of spermatogenesis, and decreased RSI were observed in male fish upon 28-d exposure to PCP. In the females, a transition from feed-forward responses to negative feedbacks of the HPG/I axis was also indicated by the transcriptional profiles at 14th and 28th day. Corresponding changes including increased E2, T and decreased C levels, degenerated ovaries, and decreased GSI and RSI were also observed. Overall, we concluded that PCP could interfere with steroid receptors, evoke responses of HPG/I axis, and finally result in adverse effects on reproductive and interrenal system in rare minnow at environmental relevant concentrations.
  • Is Part Of: Chemosphere, January 2017, Vol.166, pp.174-183
  • Identifier: ISSN: 0045-6535 ; E-ISSN: 1879-1298 ; DOI: 10.1016/j.chemosphere.2016.09.099
  • Subjects: Pentachlorophenol ; Molecular Docking ; Chinese Rare Minnow (Gobiocypris Rarus) ; Reproductive System ; Interrenal System ; Chemistry ; Ecology
  • Language: English

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