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N-Tetrahydrofuroyl-( l)-phenylalanine derivatives as potent VLA-4 antagonists

Yang, Ginger X ; Chang, Linda L ; Truong, Quang ; Doherty, George A ; Magriotis, Plato A ; de Laszlo, Stephen E ; Li, Bing ; Maccoss, Malcolm ; Kidambi, Usha ; Egger, Linda A ; Mccauley, Ermengilda ; Van Riper, Gail ; Mumford, Richard A ; Schmidt, John A ; Hagmann, William K

Bioorganic & Medicinal Chemistry Letters, 2002, Vol.12(11), pp.1497-1500 [Peer Reviewed Journal]

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Title:
N-Tetrahydrofuroyl-( l)-phenylalanine derivatives as potent VLA-4 antagonists
Author: Yang, Ginger X ; Chang, Linda L ; Truong, Quang ; Doherty, George A ; Magriotis, Plato A ; de Laszlo, Stephen E ; Li, Bing ; Maccoss, Malcolm ; Kidambi, Usha ; Egger, Linda A ; Mccauley, Ermengilda ; Van Riper, Gail ; Mumford, Richard A ; Schmidt, John A ; Hagmann, William K
Description: Given the proposed involvement of VLA-4 in inflammatory processes, a program to identify orally active VLA-4 antagonists was initiated. Herein, we report the discovery of a N-tetrahydrofuroyl-(L)-phenylalanine derivative (17) and related analogues as potent VLA-4 antagonists with good oral bioavailability.
Is Part Of: Bioorganic & Medicinal Chemistry Letters, 2002, Vol.12(11), pp.1497-1500
Identifier: ISSN: 0960-894X ; E-ISSN: 1464-3405 ; DOI: 10.1016/S0960-894X(02)00210-X
Subjects: Medicine ; Chemistry ; Anatomy & Physiology
Language: English

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