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Apolipoprotein E polymorphism affects plasma levels of lipoprotein(a)

de Knijff, Peter ; Kaptein, Allard ; Boomsma, Dorret ; Princen, Hans M.G ; Frants, Rune R ; Havekes, Louis M

Atherosclerosis, 1991, Vol.90(2), pp.169-174 [Peer Reviewed Journal]

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  • Title:
    Apolipoprotein E polymorphism affects plasma levels of lipoprotein(a)
  • Author: de Knijff, Peter ; Kaptein, Allard ; Boomsma, Dorret ; Princen, Hans M.G ; Frants, Rune R ; Havekes, Louis M
  • Description: In a group of 303 healthy Caucasian adults of both sexes we studied the influence of the apolipoprotein E (apo E) polymorphism on plasma levels of Lipoprotein(a) (Lp(a)). The APOE ∗2 allele was found to decrease the mean plasma Lp(a) level by 24.8%, whereas the APOE ∗4 allele increased the mean Lp(a) level by 25.7%. These effects were parallel to the effect of apo E polymorphism on plasma cholesterol and low density lipoprotein (LDL)-cholesterol. For the Lp(a) levels, the genetic variance associated with the APOE locus contributed about 4% to the total phenotypic variance. For plasma cholesterol and LDL-cholesterol this contribution was 4.5 and 6.3%, respectively. We also found a significant positive correlation between LDL-cholesterol and Lp(a) levels. Since the apo E polymorphism effects LDL-receptor activity, we conclude that, at least in healthy normolipidemic individuals, plasma levels of Lp(a) are modulated by the LDL-receptor activity.
  • Is Part Of: Atherosclerosis, 1991, Vol.90(2), pp.169-174
  • Identifier: ISSN: 0021-9150 ; E-ISSN: 1879-1484 ; DOI: 10.1016/0021-9150(91)90111-F
  • Subjects: Apolipoprotein E ; Lipoprotein(a) ; Genetic Polymorphism ; Apolipoprotein E ; Lipoprotein(a) ; Genetic Polymorphism ; Medicine
  • Language: English

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