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No Effect of Fibrates on Synthesis of Apolipoprotein(a) in Primary Cultures of Cynomolgus Monkey and Human Hepatocytes: Apolipoprotein A-I Synthesis Increased

Neele, Diana M ; Kaptein, Allard ; Huisman, Holger ; de Wit, Elly C.M ; Princen, Hans M.G

Biochemical and Biophysical Research Communications, 17 March 1998, Vol.244(2), pp.374-378 [Peer Reviewed Journal]

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  • Title:
    No Effect of Fibrates on Synthesis of Apolipoprotein(a) in Primary Cultures of Cynomolgus Monkey and Human Hepatocytes: Apolipoprotein A-I Synthesis Increased
  • Author: Neele, Diana M ; Kaptein, Allard ; Huisman, Holger ; de Wit, Elly C.M ; Princen, Hans M.G
  • Description: Fibrates have been shown to decrease plasma levels of triglyceride-rich lipoproteins and LDL and to increase HDL. Data on the effect of fibrates on lipoprotein(a) levels in man are not consistent. Because lp(a) levelsin vivoare mainly regulated at synthesis level, we studied the effect of fibrates on the synthesis of apolipoprotein(a) (apo(a)) in primary cultures of cynomolgus monkey and human hepatocytes. Furthermore, we assessed the effect of fibrates on apolipoprotein A-I (apo A-I) synthesis and investigated whether different fibrates have different effects on the apo(a) and apo A-I synthesis. The addition of gemfibrozil to cultures of monkey and human hepatocytes had no effect on apo(a) synthesis, but resulted in a dose- and time-dependent increase of apo A-I synthesis and mRNA. In simian hepatocytes maximal stimulation was 2.5-fold after incubation for 72 h with 1.0 mM gemfibrozil, whereas apo A-I synthesis was induced 1.8- and 2.0-fold by using 0.1 mM and 0.3 mM, respectively....
  • Is Part Of: Biochemical and Biophysical Research Communications, 17 March 1998, Vol.244(2), pp.374-378
  • Identifier: ISSN: 0006-291X ; E-ISSN: 1090-2104 ; DOI: 10.1006/bbrc.1998.8279
  • Subjects: Apolipoprotein(a) ; Apolipoprotein A-I ; Fibrates ; Cynomolgus Monkey ; and Human Hepatocytes ; Apolipoprotein(a) ; Apolipoprotein A-I ; Fibrates ; Cynomolgus Monkey ; and Human Hepatocytes ; Biology ; Chemistry ; Anatomy & Physiology
  • Language: English

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