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A simple synthesis of the metabotropic receptor ligand (2 S)-α-(hydroxymethyl)-glutamic acid and its Fmoc protected derivatives

Yiotakis, Athanasios ; Magriotis, Plato A. ; Vassiliou, Stamatia

Tetrahedron: Asymmetry, 2007, Vol.18(7), pp.873-877 [Peer Reviewed Journal]

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  • Title:
    A simple synthesis of the metabotropic receptor ligand (2 S)-α-(hydroxymethyl)-glutamic acid and its Fmoc protected derivatives
  • Author: Yiotakis, Athanasios ; Magriotis, Plato A. ; Vassiliou, Stamatia
  • Description: The highly enantioselective synthesis of (2 S)-α-(hydroxymethyl)-glutamic acid 2, a potent metabotropic receptor ligand, was accomplished using the improved Schöllkopf methodology for the construction of quaternary α-amino acids and β-lactams. This was converted to a derivative suitably protected for direct use in Fmoc solid phase peptide synthesis.
  • Is Part Of: Tetrahedron: Asymmetry, 2007, Vol.18(7), pp.873-877
  • Identifier: ISSN: 0957-4166 ; DOI: 10.1016/j.tetasy.2007.03.028
  • Subjects: Chemistry
  • Language: English

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