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Improved Schöllkopf construction of quaternary α-amino acids: efficient enantioselective synthesis of integrin LFA-1 antagonist BIRT-377

Vassiliou, Stamatia ; Magriotis, Plato A.

Tetrahedron: Asymmetry, 2006, Vol.17(11), pp.1754-1757 [Peer Reviewed Journal]

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  • Title:
    Improved Schöllkopf construction of quaternary α-amino acids: efficient enantioselective synthesis of integrin LFA-1 antagonist BIRT-377
  • Author: Vassiliou, Stamatia ; Magriotis, Plato A.
  • Description: The Schöllkopf methodology for the asymmetric synthesis of α-amino acids which was previously not applicable to the construction of α,α-dialkylated (quaternary) α-amino acids, has been rendered practical for this purpose and applied in a highly efficient enantioselective synthesis of integrin LFA-1 antagonist BIRT-377.
  • Is Part Of: Tetrahedron: Asymmetry, 2006, Vol.17(11), pp.1754-1757
  • Identifier: ISSN: 0957-4166 ; DOI: 10.1016/j.tetasy.2006.06.019
  • Subjects: Enantiomers ; Integrins ; Quaternary Period
  • Language: English

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