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Synthesis of the oxygenated pactamycin core

Knapp, Spencer ; Yu, Younong

Organic letters, 29 March 2007, Vol.9(7), pp.1359-62 [Peer Reviewed Journal]

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  • Title:
    Synthesis of the oxygenated pactamycin core
  • Author: Knapp, Spencer ; Yu, Younong
  • Description: [structure: see text]. Pactamycin, one of the most complex and densely functionalized aminocyclitol antibiotics known, presents synthetic challenges that include reactivity and sterics, relative and absolute stereochemistry, and functional group compatibility and protection. An approach is reported that features four different types of (cyclopentane) face selective functionalization reactions and results in a polyfunctionalized and appropriately protected intermediate that incorporates all the core carbons and the oxygenated functionality of the target.
  • Is Part Of: Organic letters, 29 March 2007, Vol.9(7), pp.1359-62
  • Identifier: ISSN: 1523-7060 ; PMID: 17338541 Version:1
  • Subjects: Anti-Bacterial Agents -- Chemical Synthesis ; Cyclopentanes -- Chemistry ; Oxygen -- Chemistry ; Pactamycin -- Chemical Synthesis
  • Language: English

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