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Discovery of N-(1S,2S)-3-(4-Chlorophenyl)-2- (3-cyanophenyl)-1-methylpropyl-2-methyl-2- {5-(trifluoromethyl)pyridin-2-yloxy}propanamide (MK-0364), a novel, acyclic cannabinoid-1 receptor inverse agonist for the treatment of obesity

Lin, Linus S ; Lanza, Thomas J ; Jewell, James P ; Liu, Ping ; Shah, Shrenik K ; Qi, Hongbo ; Tong, Xinchun ; Wang, Junying ; Xu, Suoyu S ; Fong, Tung M ; Shen, Chun-Pyn ; Lao, Julie ; Xiao, Jing Chen ; Shearman, Lauren P ; Stribling, D Sloan ; Rosko, Kimberly ; Strack, Alison ; Marsh, Donald J ; Feng, Yue ; Kumar, Sanjeev ; Samuel, Koppara ; Yin, Wenji ; Van Der Ploeg, Lex H T ; Goulet, Mark T ; Hagmann, William K

Journal of medicinal chemistry, 28 December 2006, Vol.49(26), pp.7584-7 [Peer Reviewed Journal]

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