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Deprotection of N-benzylbenzimidazoles and N-benzylimidazoles with triethylsilane and Pd/C

Graham, Thomas H

Tetrahedron Letters, 20 May 2015, Vol.56(21), pp.2688-2690 [Peer Reviewed Journal]

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  • Title:
    Deprotection of N-benzylbenzimidazoles and N-benzylimidazoles with triethylsilane and Pd/C
  • Author: Graham, Thomas H
  • Description: The benzyl group is a protecting group for benzimidazoles and imidazoles that can survive acidic, basic, oxidizing, and reducing conditions. Deprotection, however, can require vigorous and potentially non-chemoselective methods. The triethylsilane–Pd/C reduction system is an exceptionally mild, convenient, and efficient method for deprotecting -benzylbenzimidazoles that are unsubstituted at the 2- and 4-positions as well as suitably substituted -benzylimidazoles.
  • Is Part Of: Tetrahedron Letters, 20 May 2015, Vol.56(21), pp.2688-2690
  • Identifier: ISSN: 0040-4039 ; E-ISSN: 1873-3581 ; DOI: 10.1016/j.tetlet.2015.03.127
  • Subjects: Benzimidazole ; Imidazole ; Benzyl ; Deprotection ; Triethylsilane ; Palladium on Carbon ; Chemistry
  • Language: English
  • Source: ScienceDirect Journals (Elsevier)

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