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L-161,638: A potent AT 2selective quinazolinone angiotensin II binding inhibitor

Glinka, Tomasz W ; de Laszlo, Stephen E ; Tran, Jenifer ; Chang, Raymond S ; Chen, Tsing-Bau ; Lotti, Victor J ; Greenlee, William J

Bioorganic & Medicinal Chemistry Letters, 1994, Vol.4(12), pp.1479-1484 [Peer Reviewed Journal]

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  • Title:
    L-161,638: A potent AT 2selective quinazolinone angiotensin II binding inhibitor
  • Author: Glinka, Tomasz W ; de Laszlo, Stephen E ; Tran, Jenifer ; Chang, Raymond S ; Chen, Tsing-Bau ; Lotti, Victor J ; Greenlee, William J
  • Description: The relative AT and AT binding affinities of 6-amino-2-alkyl-3-[(2′-tetrazole-5-y)biphenyl-4-yl)methyl]quinazolin-4-(3H)-ones can be manipulated by changing the subsitution at positions C-2 and N-6 of the quinazoline nucleus. L-161,6138 was identified as a potent orally bioavailable and AT selective angiotensin II binding inhibitor. The relative At and AT binding affinities of 6-amino-2-alkyl-3-[((2′-tetrazol-5-yl)biphenyl-4-yl)methyl]quinazolin-(3H)-ones can be manipulated by changing the substitution at positions C-2 and N-6 of the quinazolinone nucleus. L-161,638 was identified as a potent orally bioavailable and AT selective angiotensin II binding inhibitor
  • Is Part Of: Bioorganic & Medicinal Chemistry Letters, 1994, Vol.4(12), pp.1479-1484
  • Identifier: ISSN: 0960-894X ; E-ISSN: 1464-3405 ; DOI: 10.1016/S0960-894X(01)80517-5
  • Subjects: Medicine ; Chemistry ; Anatomy & Physiology
  • Language: English
  • Source: ScienceDirect Journals (Elsevier)

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