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Design and synthesis of a novel photoaffinity taxoid as a potential probe for the study of paclitaxel–microtubules interactions

Lin, Songnian ; Fang, Kan ; Hashimoto, Masaru ; Nakanishi, Koji ; Ojima, Iwao

Tetrahedron Letters, 2000, Vol.41(22), pp.4287-4290 [Peer Reviewed Journal]

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  • Title:
    Design and synthesis of a novel photoaffinity taxoid as a potential probe for the study of paclitaxel–microtubules interactions
  • Author: Lin, Songnian ; Fang, Kan ; Hashimoto, Masaru ; Nakanishi, Koji ; Ojima, Iwao
  • Description: A novel and non-radioactive bifunctional photoaffinity probe (BPP) for the study of paclitaxel–microtubules interactions is designed and synthesized. This new BPP-taxoid bears a 3-nitro-5-trifluoromethyldiazirinyl-phenoxyacetyl group at C-3′N for photoaffinity/photocleavage and a biotin subunit at C-7 for affinity chromatography.
  • Is Part Of: Tetrahedron Letters, 2000, Vol.41(22), pp.4287-4290
  • Identifier: ISSN: 0040-4039 ; E-ISSN: 1873-3581 ; DOI: 10.1016/S0040-4039(00)00627-4
  • Subjects: Taxoid ; Bifunctional Probe ; Photoaffinity Label ; Biotin ; Diazirine ; Chemistry
  • Language: English

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