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Quantitatively monitoring of solid-phase organic synthesis by combustion elemental analysis

Yan, Bing ; Jewell, Charles F ; Myers, Stewart W

Tetrahedron, 1998, Vol.54(39), pp.11755-11766 [Peer Reviewed Journal]

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  • Title:
    Quantitatively monitoring of solid-phase organic synthesis by combustion elemental analysis
  • Author: Yan, Bing ; Jewell, Charles F ; Myers, Stewart W
  • Description: A systematic investigation on the role of combustion elemental analysis in the quantitative monitoring of solid-phase organic synthesis was done. Quantitative elemental analysis results obtained for eight resin-bound organic compounds are highly consistent with those obtained from well-established methods such as Fmoc method. A six-step peptoid synthesis and a dansylhydrazone synthesis were quantitatively monitored using elemental analysis. All results were corroborated by well-established photometric methods. Based on these data, the elemental analysis method is, in general, reproducible and accurate in the quantitative analysis of resin-bound organic compounds. Considering the severe shortage of on-resin quantitation methods at present, it adds a valuable tool for monitoring solid-phase organic synthesis steps that cannot be quantitated by current methods. Combustion elemental analysis is shown to be a reproducible and accurate method in the quantitative analysis of resin-bound organic compounds for the monitoring of solid-phase organic synthesis.
  • Is Part Of: Tetrahedron, 1998, Vol.54(39), pp.11755-11766
  • Identifier: ISSN: 0040-4020 ; E-ISSN: 1464-5416 ; DOI: 10.1016/S0040-4020(98)83037-8
  • Subjects: Chemistry
  • Language: English

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