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Meridamycin: A novel nonimmunosuppressive FKBP12 ligand from streptomyces hygroscopicus

Salituro, Gino M ; Zink, Deborah L ; Dahl, Arlene ; Nielsen, Jennifer ; Wu, Elizabeth ; Huang, Leeyuan ; Kastner, Carolyn ; Dumont, Francis J

Tetrahedron Letters, 1995, Vol.36(7), pp.997-1000 [Peer Reviewed Journal]

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  • Title:
    Meridamycin: A novel nonimmunosuppressive FKBP12 ligand from streptomyces hygroscopicus
  • Author: Salituro, Gino M ; Zink, Deborah L ; Dahl, Arlene ; Nielsen, Jennifer ; Wu, Elizabeth ; Huang, Leeyuan ; Kastner, Carolyn ; Dumont, Francis J
  • Description: A novel, 27-membered macrolide, meridamycin, was isolated from a strain of Streptomyces hygroscopicus and found to inhibit the binding of FK-506 to FKBP 12 and to antagonize the immunosuppressive activity of both FK-506 and rapamycin. The isolation, structure elucidation, and biological activity of this compound are described in this paper. A novel, 27-membered macrolide, meridamycin, was isolated from an unidentified strain of Streptomyces hygroscopicus and its structure was determined. Meridamycin was found to inhibit the binding of FK-506 to FKBP 12 and to antagonize the immunosuppressive activity of both FK-506 and rapamycin.
  • Is Part Of: Tetrahedron Letters, 1995, Vol.36(7), pp.997-1000
  • Identifier: ISSN: 0040-4039 ; E-ISSN: 1873-3581 ; DOI: 10.1016/0040-4039(94)02425-B
  • Subjects: Chemistry
  • Language: English

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