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Cholesterol esters selectively taken up from high-density lipoproteins are hydrolyzed extralysosomally

Sparrow, Carl P ; Pittman, Ray C

Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism, 1990, Vol.1043(2), pp.203-210

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  • Title:
    Cholesterol esters selectively taken up from high-density lipoproteins are hydrolyzed extralysosomally
  • Author: Sparrow, Carl P ; Pittman, Ray C
  • Description: High-density lipoprotein (HDL) cholesterol esters (CE) are taken up by many cells without parallel uptake of HDL apoproteins. This selective uptake is mediated by reversible incorporation of HDL CE into a plasma membrane pool, from which the CE are internalized. We now show that selectively taken up CE are directed to an extralysosomal destination where they are hydrolyzed and available to the steroidogenic pathway. Cultured human fibroblasts take up HDL CE predominantly by selective uptake. Wolman's disease fibroblasts, which are deficient in lysosomal cholesterol esterase, effectively hydrolyzed CE from HDL, but not CE taken up in low density lipoproteins (LDL); normal fibroblasts hydrolyzed both effectively. Analogously, the lysosomotropic agent chloroquine effectively blocked hydrolysis of LDL CE but not HDL CE. A similar effect of chloroquine was seen in primary cultures of rat adrenal cells, which are very active in selective uptake. More than 50% of HDL CE taken up by adrenal...
  • Is Part Of: Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism, 1990, Vol.1043(2), pp.203-210
  • Identifier: ISSN: 0005-2760 ; DOI: 10.1016/0005-2760(90)90297-B
  • Subjects: HDL ; Cholesterol Ester Metabolism ; Adrenal ; Lipid Storage Droplet ; Steroidogenesis ; Cholesterol Esterase ; HDL ; Cholesterol Ester Metabolism ; Adrenal ; Lipid Storage Droplet ; Steroidogenesis ; Cholesterol Esterase ; HDL ; LDL ; CE ; Cet ; Cetp ; ∗ I-Nmtc ; ∗I-TC
  • Language: English
  • Source: ScienceDirect Journals (Elsevier)

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