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Structural modifications of benzanilide derivatives, effective potassium channel openers. X

Calderone, Vincenzo ; Coi, Alessio ; Fiamingo, Francesca Lidia ; Giorgi, Irene ; Leonardi, Michele ; Livi, Oreste ; Martelli, Alma ; Martinotti, Enrica

European journal of medicinal chemistry, December 2006, Vol.41(12), pp.1421-9 [Peer Reviewed Journal]

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  • Title:
    Structural modifications of benzanilide derivatives, effective potassium channel openers. X
  • Author: Calderone, Vincenzo ; Coi, Alessio ; Fiamingo, Francesca Lidia ; Giorgi, Irene ; Leonardi, Michele ; Livi, Oreste ; Martelli, Alma ; Martinotti, Enrica
  • Description: Large-conductance calcium-activated potassium (BK) channels are involved in many fundamental cell functions. Consistently, the ability to activate BK channels by exogenous compounds is considered as a promising pharmacodynamic pattern for the potential treatment of several pathologies. In this perspective, the development of new and selective BK-openers can be considered as an actual field of research. This paper reports the synthesis and pharmacological evaluation of new benzanilides, useful for deepening the comprehension of the structure-activity relationships, emerged in previous studies on this class of BK-activators. From a structural point of view, these benzanilides belong to a general class of BK-activators, showing a common pharmacophoric model, consisting of two aryl groups linked through an appropriate "spacer" and the almost obligatory presence of a phenolic hydroxyl. In particular, a new series of benzanilides, in which the phenyl rings have been widely changed both on the...
  • Is Part Of: European journal of medicinal chemistry, December 2006, Vol.41(12), pp.1421-9
  • Identifier: ISSN: 0223-5234 ; PMID: 17030483 Version:1
  • Subjects: Anilides -- Chemistry ; Potassium Channels -- Agonists
  • Language: English
  • Source: MEDLINE/PubMed (U.S. National Library of Medicine)

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