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Modulation of anxiety behavior in the elevated plus maze using peptidic oxytocin and vasopressin receptor ligands in the rat

Mak, Plato ; Broussard, Christina ; Vacy, Kristina ; Broadbear, Jillian H

Journal of Psychopharmacology, April 2012, Vol.26(4), pp.532-542 [Peer Reviewed Journal]

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  • Title:
    Modulation of anxiety behavior in the elevated plus maze using peptidic oxytocin and vasopressin receptor ligands in the rat
  • Author: Mak, Plato ; Broussard, Christina ; Vacy, Kristina ; Broadbear, Jillian H
  • Description: Oxytocin (OT) and arginine vasopressin (AVP), in their capacities as neuromodulators, are believed to play an important role in mood control, including regulation of the anxiety response. In the present study, the contributions of oxytocin and vasopressin receptor modulation to anxiety-like behaviors were examined in male Sprague-Dawley rats. The behavioral effects of the OT receptor agonist, carbetocin (intracerebroventricular, intravenous and intraperitoneal routes), the AVP receptor agonist desmopressin (intravenous route), and the OT/AVP1A receptor antagonist atosiban (intravenous route) were evaluated in the elevated plus maze. The benzodiazepine diazepam was included as a positive control. Central but not systemic administration of carbetocin produced pronounced anxiolytic-like behavioral changes comparable to those measured following systemic diazepam treatment. The anxiolytic efficacy of carbetocin was maintained following 10 days of once-daily treatment, contrasting...
  • Is Part Of: Journal of Psychopharmacology, April 2012, Vol.26(4), pp.532-542
  • Identifier: ISSN: 0269-8811 ; E-ISSN: 1461-7285 ; DOI: 10.1177/0269881111416687
  • Subjects: Anxiolytic ; Atosiban ; Carbetocin ; Desmopressin ; Diazepam ; Elevated Plus Maze ; Oxytocin ; Sprague-Dawley Rat ; Vasopressin ; Pharmacy, Therapeutics, & Pharmacology ; Psychology
  • Language: English

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