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CoreShell Structure and Aggregation Number of Micelles Composed of Amphiphilic Block Copolymers and Amphiphilic Heterografted Polymer Brushes Determined by Small-Angle X-ray Scattering

Szymusiak, Magdalena ; Kalkowski, Joseph ; Luo, Hanying ; Donovan, Alexander J ; Zhang, Pin ; Liu, Chang ; Shang, Weifeng ; Irving, Thomas ; Herrera-Alonso, Margarita ; Liu, Ying Argonne National Lab. (Anl), Argonne, Il (United States). Advanced Photon Source (APS) (Corporate Author)

ACS Macro Letters, 31 August 2017, Vol.6(9)

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  • Title:
    CoreShell Structure and Aggregation Number of Micelles Composed of Amphiphilic Block Copolymers and Amphiphilic Heterografted Polymer Brushes Determined by Small-Angle X-ray Scattering
  • Author: Szymusiak, Magdalena ; Kalkowski, Joseph ; Luo, Hanying ; Donovan, Alexander J ; Zhang, Pin ; Liu, Chang ; Shang, Weifeng ; Irving, Thomas ; Herrera-Alonso, Margarita ; Liu, Ying
  • Argonne National Lab. (Anl), Argonne, Il (United States). Advanced Photon Source (APS) (Corporate Author)
  • Description: A large group of functional nanomaterials employed in biomedical applications, including targeted drug delivery, relies on amphiphilic polymers to encapsulate therapeutic payloads via self-assembly processes. Knowledge of the micelle structures will provide critical insights into design of polymeric drug delivery systems. Coreshell micelles composed of linear diblock copolymers poly(ethylene glycol)-b-poly(caprolactone) (PEG-b-PCL), poly(ethylene oxide)-b-poly(lactic acid) (PEG-b-PLA), as well as a heterografted brush consisting of a poly(glycidyl methacrylate) backbone with PEG and PLA branches (PGMA-g-PEG/PLA) were characterized by dynamic light scattering (DLS) and small-angle X-ray scattering (SAXS) measurements to gain structural information regarding the particle morphology, coreshell size, and aggregation number. The structural information at this quasi-equilibrium state can also be used as a reference when studying the kinetics of polymer micellization.
  • Is Part Of: ACS Macro Letters, 31 August 2017, Vol.6(9)
  • Identifier: ISSN: 2161-1653 ; E-ISSN: 2161-1653 ; DOI: 10.1021/acsmacrolett.7b00490
  • Subjects: Materials Science ; 60 Applied LIFE Sciences ; Chemistry
  • Language: English
  • Source: SciTech Connect (U.S. Dept. of Energy - Office of Scientific and Technical Information)

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