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Long-term increases in renal sympathetic nerve activity and hypertension

Osborn, J L ; Plato, C F ; Gordin, E ; He, X R

Clinical and experimental pharmacology & physiology, January 1997, Vol.24(1), pp.72-6 [Peer Reviewed Journal]

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  • Title:
    Long-term increases in renal sympathetic nerve activity and hypertension
  • Author: Osborn, J L ; Plato, C F ; Gordin, E ; He, X R
  • Description: 1. Essential hypertensive patients have been characterized by increased sympathetic nerve activity, increased peripheral vascular tone, decreased plasma volume and normal cardiac output when compared with normotensive subjects. Bilateral renal denervation reduces the magnitude or delays the onset of the blood pressure response in numerous models of experimental hypertension regardless of the aetiology of the elevation in arterial pressure. 2. Using a servocontrolled intrarenal infusion system, we have elevated intrarenal noradrenaline concentration via intermittent renal artery infusion without decreasing renal blood flow as a method of simulating selective elevation of renal sympathetic outflow. 3. Chronic intrarenal adrenergic stimulation increased arterial pressure within 24 h and this hypertension persisted for 28 consecutive days. The elevated arterial pressure was not associated with sustained increases in plasma renin activity, aldosterone, circulating catecholamines, arginine vasopressin...
  • Is Part Of: Clinical and experimental pharmacology & physiology, January 1997, Vol.24(1), pp.72-6
  • Identifier: ISSN: 0305-1870 ; PMID: 9043809 Version:1
  • Subjects: Hypertension -- Physiopathology ; Sympathetic Nervous System -- Physiology
  • Language: English
  • Source: MEDLINE/PubMed (U.S. National Library of Medicine)

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