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Updated Nomogram to Predict Pathologic Stage of Prostate Cancer Given Prostate-Specific Antigen Level, Clinical Stage, and Biopsy Gleason Score (Partin Tables) Based on Cases from 2000 to 2005

Makarov, Danil V ; Trock, Bruce J ; Humphreys, Elizabeth B ; Mangold, Leslie A ; Walsh, Patrick C ; Epstein, Jonathan I ; Partin, Alan W

Urology, 2007, Vol.69(6), pp.1095-1101 [Peer Reviewed Journal]

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  • Title:
    Updated Nomogram to Predict Pathologic Stage of Prostate Cancer Given Prostate-Specific Antigen Level, Clinical Stage, and Biopsy Gleason Score (Partin Tables) Based on Cases from 2000 to 2005
  • Author: Makarov, Danil V ; Trock, Bruce J ; Humphreys, Elizabeth B ; Mangold, Leslie A ; Walsh, Patrick C ; Epstein, Jonathan I ; Partin, Alan W
  • Description: To update the 2001 “Partin tables” with a contemporary patient cohort and revised variable categorization, correcting for the effects of stage migration. We analyzed 5730 men treated with prostatectomy (without neoadjuvant therapy) between 2000 and 2005 at the Johns Hopkins Hospital. Average age was 57 years. Multivariable logistic regression was used to estimate the probability of organ-confined disease, extraprostatic extension, seminal vesicle involvement, or lymph node involvement. Predictor variables included preoperative prostate-specific antigen (PSA) level (0 to 2.5, 2.6 to 4.0, 4.1 to 6.0, 6.1 to 10.0, and greater than 10.0 ng/mL), clinical stage (T1c, T2a, and T2b/T2c), and biopsy Gleason score (5 to 6, 3 + 4 = 7, 4 + 3 = 7, or 8 to 10). Bootstrap resampling was used to generate 95% confidence intervals for predicted probabilities. Seventy-seven percent of patients had T1c, 76% had Gleason score 5 to 6, 80% had a PSA level between...
  • Is Part Of: Urology, 2007, Vol.69(6), pp.1095-1101
  • Identifier: ISSN: 0090-4295 ; E-ISSN: 1527-9995 ; DOI: 10.1016/j.urology.2007.03.042
  • Subjects: Medicine
  • Language: English

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