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Structural and neurochemical comparison of vagal and spinal afferent neurons projecting to the rat lung

Plato, Malte ; Kummer, Wolfgang ; Haberberger, Rainer V

Neuroscience Letters, 2006, Vol.395(3), pp.215-219 [Peer Reviewed Journal]

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  • Title:
    Structural and neurochemical comparison of vagal and spinal afferent neurons projecting to the rat lung
  • Author: Plato, Malte ; Kummer, Wolfgang ; Haberberger, Rainer V
  • Description: Afferent information from the lung is conveyed both to the brainstem and to the spinal cord by primary afferent fibres originating from vagal sensory (jugular-nodose ganglion complex = JNC) and dorsal root ganglion (DRG) neurons, respectively. Most interest, so far, has been paid to the vagal pathway while much less is known about spinal afferents. Here we provide the first direct comparison of rat pulmonary spinal and vagal pulmonary afferent neurons with respect to structural (soma size) and two neurochemical characteristics (binding of lectin IB4, immunoreactivity to calcitonin gene-related peptide = CGRP). After retrograde labelling from the lung, all possible combinations of CGRP-immunoreactivity and IB4-binding were observed, and the neurochemically defined subpopulations occurred in the same order of frequency in DRG and JNC: (1) IB4 /CGRP ...
  • Is Part Of: Neuroscience Letters, 2006, Vol.395(3), pp.215-219
  • Identifier: ISSN: 0304-3940 ; E-ISSN: 1872-7972 ; DOI: 10.1016/j.neulet.2005.10.078
  • Subjects: Jugular-Nodose Ganglion Complex ; DRG ; Cgrp ; Ib4 ; Tracing ; Immunohistochemistry ; Medicine ; Anatomy & Physiology
  • Language: English

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