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Embryocidal action of a bis(dichloroacetyl)-diamine: An oral abortifacient for rats

Oster, Gerald ; Salgo, Miklos P ; Taleporos, Plato

American Journal of Obstetrics and Gynecology, 01 July 1974, Vol.119(5), pp.583-588 [Peer Reviewed Journal]

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  • Title:
    Embryocidal action of a bis(dichloroacetyl)-diamine: An oral abortifacient for rats
  • Author: Oster, Gerald ; Salgo, Miklos P ; Taleporos, Plato
  • Description: N,N′-bis(dichloroacetyl)-1,8-octamethylenediamine (Win 18,446), previously used to suppress spermatogenesis in man and other mammals, is shown to be an effective oral abortifacient for rats. When administered at the appropriate dosage and time of gestation, the drug produces the resorption of 100 per cent of the embryos, with no toxic effect to the mother. The optimal regimen for embryocidal action is 200 mg. daily for days 10 and 11 after mating. A mechanism is proposed involving mitochondrial function and replication to explain the action of this drug in the inhibition of embryonic development as well as the suppression of spermatogenesis.
  • Is Part Of: American Journal of Obstetrics and Gynecology, 01 July 1974, Vol.119(5), pp.583-588
  • Identifier: ISSN: 0002-9378 ; E-ISSN: 1097-6868 ; DOI: 10.1016/0002-9378(74)90117-3
  • Subjects: Medicine
  • Language: English
  • Source: ScienceDirect Journals (Elsevier)

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